What is 1,2-diethoxyethane (CAS 629-14-1)? Safety, Regulation & EU/US/Canada Perspective

Sources: REACH SVHC Candidate List — European Chemicals Agency (ECHA) · last fetched 2026-06-07

1,2-diethoxyethane, also known by its CAS number 629-14-1, is a chemical substance that has garnered attention from regulatory bodies worldwide. This explainer aims to provide an overview of the substance, its uses, and the reasons behind regulatory tracking.

What 1,2-diethoxyethane is

1,2-diethoxyethane is a synthetic chemical compound that belongs to the class of ethers. It is a colorless liquid with a mild, sweet odor. The substance is used as a solvent in various industrial applications, including the production of coatings, adhesives, and cleaning agents. Its chemical properties make it a useful intermediate in the manufacture of other chemicals.

Why regulators track it

Regulatory bodies track 1,2-diethoxyethane due to concerns over its potential impact on human health and the environment. The substance has been identified as a Substance of Very High Concern (SVHC) by the European Chemicals Agency (ECHA) and is listed on the REACH SVHC Candidate List. This listing is based on the substance's potential to cause harm to human health or the environment, and it triggers certain notification and communication duties for suppliers and manufacturers. The reason for its listing is related to regulatory tracking under the REACH framework, which aims to ensure the safe use of chemicals in the European Union.

European Union perspective

In the European Union, 1,2-diethoxyethane is subject to the REACH Regulation (EC) No 1907/2006. As a substance on the SVHC Candidate List, manufacturers and importers of 1,2-diethoxyethane are required to notify ECHA and provide information on the substance's uses, risks, and safe handling practices. The listing also means that the substance may be considered for inclusion in Annex XIV of the REACH Regulation, which would require authorization for its use. The European Union's regulatory approach is designed to minimize the risks associated with the substance and ensure that it is used in a safe and controlled manner.

United States perspective

In the United States, 1,2-diethoxyethane is subject to regulation under the Toxic Substances Control Act (TSCA). The US Environmental Protection Agency (EPA) is responsible for regulating the substance and ensuring that its use does not pose an unreasonable risk to human health or the environment. While 1,2-diethoxyethane is not currently listed as a hazardous substance under TSCA, the EPA may still require reporting and testing for the substance under certain circumstances.

Canada perspective

In Canada, 1,2-diethoxyethane is regulated under the Canadian Environmental Protection Act, 1999 (CEPA 1999). Health Canada and Environment and Climate Change Canada (ECCC) are responsible for assessing the risks associated with the substance and ensuring that its use is safe for human health and the environment. The substance may be subject to reporting and testing requirements under CEPA 1999, and its use may be restricted or prohibited if it is found to pose an unacceptable risk.

Where it shows up in consumer products

1,2-diethoxyethane may be present in a variety of consumer products, including cleaning agents, adhesives, and coatings. It is often used as a solvent or intermediate in the manufacture of these products. Consumers may be exposed to the substance through inhalation, skin contact, or ingestion, although the risks associated with exposure are generally considered to be low. It is still important for consumers to follow safe handling practices and use products containing 1,2-diethoxyethane in accordance with the manufacturer's instructions.

If you think you have been exposed

If you think you have been exposed to 1,2-diethoxyethane, it is essential to consult a doctor, occupational health specialist, or poison control center for advice. These professionals can assess your exposure and provide guidance on any necessary medical treatment or follow-up. It is crucial to seek medical attention if you experience any symptoms or health effects that you believe may be related to exposure to 1,2-diethoxyethane. For more information on the substance and its regulatory status, users can verify the information on the ECHA website or consult with relevant regulatory agencies.

Verify on the primary regulator's register

• European Chemicals Agency (ECHA) — REACH SVHC Candidate List →
• CAS Common Chemistry — CAS 629-14-1 →
• ECHA chemical search (CAS 629-14-1) →

If you have an exposure concern

If you suspect acute exposure, contact your poison-control centre. For long-term concerns, speak with a occupational-health physician or your family doctor. ProductGuru does not provide medical advice.

• US National Poison Control (1-800-222-1222) →
• EU national poison centres (ECHA directory) →
• Canada provincial poison centres (CAPCC) →

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