New Safety Information: Interaction of Proton Pump Inhibitors (PPIs)… — recall 25435
Government of Canada recall portal · Canada · 2012-10-19
As described by Government of Canada recall portal: New Safety Information: Interaction of Proton Pump Inhibitors (PPIs) with Methotrexate
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Reported risk: Health Canada is informing Canadians and Canadian health care practitioners that the labelling for methotrexate and Proton Pump Inhibitors is being updated to include information on a potential interaction between these products. The new information will be in the "Warnings and Precautions" section of the methotrexate and the PPIs labelling. Methotrexate is used at high doses in the treatment of cancer and at much lower dose in the treatment of autoimmune diseases. Proton pump inhibitors are acid reducers used in the treatment of heartburn or acid indigestion.
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